- Recipient of the 2016 IEEE Neural Networks Pioneer Award
- Elected founding member of the Cyprus Academy of Sciences, Letters, and Arts (2019)
- Recipient of the Cyprus Distinguished Researcher Award (awarded on behalf of the President of Cyprus in a high profile ceremony in November 2015)
- IEEE Fellow — for contributions to the theory and application of intelligent systems and control, (2006).
- IFAC Fellow (2016)
- Recipient of the Research Excellence Award from the University of Cyprus (June 2015)
- Awarded the 2014 Best Paper Award in the journal Building and Environment (Elsevier) for the paper entitled Contaminant Event Monitoring in Multi-zone Buildings Using the State-Space Method, co-authored by M. P. Michaelides, V. Reppa, M. Christodoulou, C. Panayiotou and M. Polycarpou, vol. 71, pp. 140-152, January 2014
- Graduate student Efrain Morales won the “Student Best Paper Award” 1999 IEEE International Conference on Control Applications for the paper entitled “Adaptive Control of Peristaltic Pumps during Continuous Venovenous Hemofiltration,” which was co-authored by Morales, Polycarpou, Hemasilpin and Bissler (August 1999)
- Recipient of the William H. Middendorf Research Excellence Award, University of Cincinnati, 1997
- Nominated by students for the Professor of the Year award for the academic year 1995-96, College of Engineering Tribunal
- Nominated by students for the Professor of the Quarter award for the academic quarter Winter 1997, College of Engineering Tribunal
- Graduate Student Xiaodong Zhang was the recipient of the “Best Ph.D. Dissertation Award”, ECE/CS Department, University of Cincinnati, 2002
- Graduate Student Scott Weaver was the recipient of the “Best Ph.D. Dissertation Award”, ECE/CS Department, University of Cincinnati, 1999
- Graduate Student Michael Zierolf was the recipient of the “Best M.S. Thesis Award”, ECE/CS Department, University of Cincinnati , 1997
- Graduate Student Efrain Morales was the recipient of honorable mention for the “Best M.S. Thesis Award”, ECE/CS Department, University of Cincinnati, 1999
- Graduate Student Arun Vemuri was the recipient of honorable mention for the “Best Ph.D. Dissertation Award”, ECE/CS Department, University of Cincinnati, 1997
- Recipient of Best Paper Presentation Award at the 1992 AIAA Guidance, Navigation and Control Conference for the paper entitled “Identification and Control of Aircraft Dynamics Using Radial Basis Function Neural Networks”
- Recipient of Best Paper Presentation Award at the 1991 American Control Conference for the paper entitled “Learning Techniques for Structured Networks”
- Recipient of Honorable Mention in Phi Kappa Phi National Honor Society’s Student Recognition Award (1992)
- Recipient of Outstanding Academic Achievement Award, University of Southern California (1992)
- Recipient of the Phi Beta Kappa Award, Rice University (1987)